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Protein, Total, Serum

Protein, Total, Serum

Epic Mnemonic
Sunquest Mnemonic

LAB118
TP

Category

Chemistry

Methodology

Colorimetric

Test Performance Schedule

Sunday - Saturday

Result Availability

Within 24 hours – STAT upon request

Specimen Required

Container

Gold top (SST), Red top (serum), or Green top (lithium heparin) tube

Volume

Pref. Vol.: 1.0 mL serum or plasma
Min. Vol.: 0.5 mL serum or plasma

Collection Instructions

• Routine venipuncture

• Immediately after collection, gently invert tube 5-10 times

• Clot 30 minutes

• Promptly centrifuge 10 minutes

• If no gel barrier is present immediately transfer serum or plasma to a plastic tube and refrigerate

Transportation Instructions

Refrigerate

Stability

• Refrigerated: 5 days

CPT Codes

84155

Effective/Revised

03/29/2017

Clinical Significance

Plasma proteins are synthesized predominantly in the liver, plasma cells, lymph nodes, the spleen and in bone marrow. In the course of disease the total protein concentration and also the percentage represented by individual fractions can significantly deviate from normal values.

 

Hypoproteinemia can be caused by diseases and disorders such as loss of blood, sprue, nephrotic syndrome, severe burns, salt retention syndrome and Kwashiorkor (acute protein deficiency). Hyperproteinemia can be observed in cases of severe dehydration and illnesses such as multiple myeloma.

 

Changes in the relative percentage of plasma proteins can be due to a change in the percentage of one plasma protein fraction. Often in such cases the amount of total protein does not change. The A/G ratio is commonly used as an index of the distribution of albumin and globulin fractions. Marked changes in this ratio can be observed in cirrhosis of the liver, glomerulonephritis, nephrotic syndrome, acute hepatitis, lupus erythematosus as well as in certain acute and chronic inflammations.

 

Total protein measurements are used in the diagnosis and treatment of a variety of diseases involving the liver, kidney, or bone marrow, as well as other metabolic or nutritional disorders.

 

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