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Kappa/Lambda Free Light Chains, Quantitative Serum

Kappa/Lambda Free Light Chains, Quantitative, w/ Ratio, Serum

Alternate Test Name

Kappa and Lambda Free Light Chains

Epic Mnemonic
Sunquest Mnemonic

LAB735
KLB

Category

Sendouts

Methodology

Turbidimetry

Test Performance Schedule

Monday, Wednesday, Friday

Result Availability

1 – 5 days

Specimen Required

Container

Gold top (SST) tube

Volume

Pref. Vol.: 5.0 mL
Min. Vol.: 2.0 mL

Collection Instructions

• Routine venipuncture
Immediately after collection, gently invert tube 5-10 times
• Clot 30 minutes
• Promptly centrifuge 15 minutes
• Refrigerate within 2 hours of collection

Transportation Instructions

Refrigerated

Stability

• Room Temperature: 8 hours
• Refrigerated (preferred): 7 days
• Frozen: Aliquot serum for longer storage

Remarks

Test includes:
Kappa free light chain
Lambda free light chain
Kappa Lambda FLC ratio
KL prozone

CPT Codes

83883 x 2

Effective/Revised

11/19/2019

Clinical Significance

Free light chains (FLC) is a more sensitive test than serum or urine immunofixation (IF) and it is a valuable tool for diagnosing and monitoring patients with secretory and nonsecretory multiple myeloma. Nearly all multiple myeloma patients have increased FLC. Monitoring of FLC provides a quicker indication of response to therapy than monoclonal or total immunoglobulins due to its shorter half-life and the larger clinical ranges of FLC concentrations. 100% of patients with light-chain multiple myeloma, 75% with nonsecretory myeloma, and more than 95% with primary amyloidosis could be diagnosed using FLC.

 

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